Interventional Effect of Glycyrrhizin on Hydroxyproline,Hyaluronic Acid,and Laminin in Pulmonary Fibrosis Model Rats
- VernacularTitle:甘草酸对肺纤维化模型大鼠羟脯氨酸、玻璃酸、层粘连蛋白的干预作用
- Author:
Xiaohua LV
;
Tie WU
;
Dongyun QIN
- Publication Type:Journal Article
- Keywords:
Glycyrrhizin;
Pulmonary fibrosis;
Rat;
Hyaluronic acid;
Laminin
- From:
China Pharmacy
2007;0(25):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To observe the effects of glycyrrhizin on hydroxyproline(HYP),hyaluronic acid(HA) and laminin(LN) in pulmonary fibrosis model rats.METHODS: A total of 80 SD rats were randomly divided into normal control group,model group,hormone group(prednisone 0.6 mg?kg?d-1),and glycyrrhizin group(10 g?kg?d-1).The latter 3 groups were established into pulmonary fibrosis model with bleomycin,and on the second day after modelling,each group was given corresponding test drugs(the normal group and model group were treated with same amount of normal saline) then the changes of the levels of HYP in lung tissues,and serum levels of HA and LN in every group were observed at 7 and 28 days respectively.RESULTS: In glycyrrhizin group compared with model group,the contents of HYP in lung tissue,HA and LN in serum decreased significantly(P
