Protective Effect of Captopril on Nicotine-induced Endothelial Dysfunction in Rats
- VernacularTitle:卡托普利对尼古丁所致大鼠血管内皮功能损伤的保护作用
- Author:
Hongli LUO
;
Shunlin XIAO
;
Yun YE
;
Liqun LEI
- Publication Type:Journal Article
- Keywords:
Captopril;
Nicotine;
Rat;
Endothelium-dependent relaxation
- From:
China Pharmacy
2007;0(25):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To discuss the protective effect of captopril on the nicotine-induced impairment of endothelium-dependent relaxation(EDR) in rat mesenteric arteries and explore the possible mechanisms underlying the observed protective effects of captopril.METHODS: A total of 30 rats were randomly divided into 3 groups: normal control group,nicotine group(2 mg?kg-1),captopril group(nicotine 2 mg?kg-1+captopril 3 mg?kg-1).After treatment for 4 weeks,vasodilatation rate of mesenteric arteries,the content of NO and NOS,and the SOD activities in serum were measured.RESULTS: Nicotine significantly decreased the vasodilatation rate of mesenteric arteries and decreased the content of NO and NOS,SOD activities in serum(P
