Effect of Lipid Diet on Pharmacokinetics of Gatifloxacin
- VernacularTitle:脂质饮食对加替沙星药动学的影响
- Author:
Bin ZHANG
;
Huarong WANG
- Publication Type:Journal Article
- Keywords:
Lipid diet;
Gatifloxacin;
Pharmacokinetics;
Dogs
- From:
China Pharmacy
2007;0(25):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To study the effect of lipid diet on the pharmacokinetics of gatifloxacin.METHODS: 8 Beagle dogs were randomly assigned to receive single oral dose of gatifloxacin capsules(17 mg?kg-1) on empty stomach or in combination with lipid diet by a randomized crossover design plasma concentrations of gatifloxacin were measured by HPLC.The pharmacokinetic parameters were calculated by 3p97,and the effect of the lipid diet on the pharmacokinetics of gatifloxacin was evaluated.RESULTS: The concentration-time curves fitted one compartment model in empty stomach group and lipide diet group.The main pharmacokinetic parameters were as follows: t1/2ke were(4.00?0.84) and(7.87?1.54) h;tmax(2.29?1.08) and(3.61?2.72) h;Cmax(6.06?0.87) and(2.91?1.27) ?g?mL-1;AUC(0～t)(56.74?10.80) and(45.35?10.81) ?g?h?mL-1,respectively There were significant differences between the two groups in the t1/2Ke and Cmax(P
