Preparation of Diclofenac Sodium Microemulsion with Poloxamer 188 as Coemulsifier
- VernacularTitle:以泊洛沙姆188为助乳化剂制备双氯芬酸钠亚微乳的研究
- Author:
Hao WANG
;
Jijin GU
;
Yingjie DENG
- Publication Type:Journal Article
- Keywords:
Lipo-submicroemulsion;
Poloxamer 188;
Diclofenac sodium;
Entrapment efficiency;
Particle size;
?-electric potential
- From:
China Pharmacy
2007;0(25):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the effect of poloxamer 188 as co-emulsifier on the pharmaceutical property of emulsion.METHODS: Diclofenac sodium was used as model drug and poloxamer 188 as co-emulsifier,the emulsion was prepared by high pressure homogen-colostrum pH adjusting method,with its entrapment efficiency,particle size,?-electric potential etc determined.RESULTS: The emulsion which was added with poloxamer 188 showed decreased entrapment efficiency and ?-electric potential but increased particle size as comapred with the one without poloxamer 188.CONCLUSION: The pharmaceutical property of emulsion wouldn't necessarily be enhanced by adding poloxamer 188 as co-emulsifier.
