Preparation and Quality Control of Thermosensitive Meloxicam Hydrogel
- VernacularTitle:美洛昔康温敏性水凝胶的制备及质量控制
- Author:
Xianling SHEN
;
Yan HU
;
Lu LEI
;
Chuanxin XU
- Publication Type:Journal Article
- Keywords:
Meloxicam;
Thermosensitive hydrogel;
Poloxamer;
Ultraviolet spectrophotometry;
Quality control
- From:
China Pharmacy
2007;0(25):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To prepare thermosensitive meloxicam hydrogel and establish its quality control method.METHODS: The hydrogel was prepared with poloxamer 407 and poloxamer 188 as base.The content of meloxicam in the thermosensitive gel was determined by UV spectrophotometry.RESULTS: The thermosensitive meloxicam hydrogel was yellowish or flavovirens in color,with its identification and tests all in conformity with the related specification stated in Chinese Pharmacopeia(2005 edition).The linear response range of meloxican was 1.956~19.56 mg?L-1(r=0.999 7).The average recovery was 98.42%(RSD=1.53%).CONCLUSION: The preparative technique is simple,and the quality of the preparation is controllable.