Effects of Egb761 on the Expression of Matrix Metalloproteinase-9/Tissue Inhibitor of Metallopro-teinase-1 in Asthmatic Model Rats and Its Intervention on Airway Remodeling
- VernacularTitle:Egb761对哮喘模型大鼠MMP-9及TIMP-1表达的影响和对气道重构的干预研究
- Author:
Jiazhen WANG
;
Tianqing WU
;
Liyuan ZHOU
- Publication Type:Journal Article
- Keywords:
Extract of Ginkgo biloba;
Matrix metalloproteinase;
Airway remodeling;
Asthma
- From:
China Pharmacy
2005;0(24):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the effects of extract of Ginkgo biloba(Egb761) on the expression of matrix metalloproteinase-9(MMP-9) and tissue inhibitor of metalloproteinase-1(TIMP-1) and evaluate its intervention effect on airway remodeling in asthmatic rats model. METHODS: Rats were randomly assigned to normal control, asmatic group, Dexamethasone (DXM) group and Egb761 group. The asmatic model was established in rats. The changes of airway morphologic parameter and the relative content of MMP-9 and TIMP-1 in bronchial epithelium in these groups were determined using immunohistochemical technique and computer assisted image analysis system. RESULTS: The thickness of airway wall and airway smooth muscle was obviously thicker in the asthmatic group than any other group (P
