Effects of Antihypertensive Protein from Pheretima on Angiotensin Ⅱ and Angiotensin Ⅱ AT_1 Receptor in Spontaneously Hypertensive Rats
- VernacularTitle:地龙降压蛋白对自发性高血压模型大鼠血管紧张素Ⅱ及AT_1受体表达的影响研究
- Author:
Chengde LI
;
Shumei MAO
;
Bai KANG
- Publication Type:Journal Article
- Keywords:
Antihypertensive protein from Pheretima;
Spontaneously hypertensive rat(SHR);
AngiotensinⅡ;
Angiotensin ⅡAT1 receptor
- From:
China Pharmacy
2005;0(24):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of the antihypertensive protein from Pheretima on blood pressure, angiotensinⅡ and angiotensin Ⅱ AT1 receptor in spontaneously hypertensive rats (SHR).METHODS: The dynamic change of blood pressure in SHR after singel intravenous injection of antihypertensive protein from Pheretima was observed. After intervention with antihypertensive protein from earthworm for 28 d,the levels of blood pressure, angiotensinⅡ and expression of angiotensin Ⅱ AT1 receptor in SHR were detected. RESULTS: Either single intravenous injecion or multiple dosing of the antihypertensive protein from Pheretima could significantly reduce the blood pressure in SHR (P0.05).The expression of angiotensin Ⅱ AT1 receptor in kidney of SHR model increased significanlty compared the normal control (wistar rats), but decreased after the intervention of the antihypertensive protein from Pheretima.CONCLUSION: The antihypertensive protein from Pheretima has antihypertensive effect on SHR. The mechanism may be related to the reduction of angiotensinⅡ level and lowering of the expression of a angiotensin Ⅱ AT1 receptor in kidney.
