Effect of Shenshuaining Dispersible Tablets on Serum NO,NOS,SOD and MDA Levels in Rats with Chronic Renal Failure
- VernacularTitle:肾衰宁分散片对慢性肾衰竭模型大鼠血清NO、NOS、SOD和MDA水平的影响研究
- Author:
Yun MA
;
Lianbing HOU
- Publication Type:Journal Article
- Keywords:
Shenshuaining dispersible tablets;
Chronic renal failure;
Nitric oxide;
Free radical
- From:
China Pharmacy
2005;0(24):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To observe the effect of Shenshuaining dispersible tablets on renal function of rats with chronic renal failure (CRF) induced by adenine and explore its action mechanism. METHODS: Seventy-two Sprague-Dawley rats (the ratio of male to female was 1∶1) were randomly divided into 6 groups: normal control group, model control group, Niaoduqing group, Shenshuaining dispersible tablets groups (high, middle and low doses). All groups except the normal control were fed with feed containing 0.5% adenine to estabish CRF model. After giving corresponding drugs for 7 weeks, the levels of nitric oxide (NO), total nitric oxide synthase (T-NOS), inducing nitric oxide synthase (iNOS), configuration nitric oxide synthase (cNOS), total superoxide dismutase (SOD), Cu/Zn-SOD and malonaldehyde (MDA) were detected. RESULTS: Compared with normal control group, the levels of NO,T-NOS, cNOS, T-SOD and Cu/Zn-SOD markedly decreased, and the iNOS and MDA contents were significantly increased in adenine-induced CRF rats. Shenshuaining dispersible tablets could markedly ameliorate the above indexes. CONCLUSION: Shenshuaining dispersible tablets could effectively ameliorate renal function. The mechanism might be related to the enhanced body's antioxidation abiliy, reduced damage of free radical and increased synthesis of cNOS and NO which possess protective effect on renal function.
