Optimization of Basic Formula of Compound Salicylic Acid and Chloramphenicol Gel with Orthogonal Test
- VernacularTitle:正交试验优选复方水杨酸氯霉素凝胶基质
- Author:
Jianmei HU
;
Peijian LIU
;
Canghai XU
- Publication Type:Journal Article
- Keywords:
Salicylic acid;
Chloramphenicol;
Base formula
- From:
China Pharmacy
2005;0(24):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize the basic formula of Compound Salicylic Acid and Chloramphenicol Gel with orthogonal design test.METHODS:The closage of CMC-Na、glycerin and ethanol were taken as the review object with the oligation grade as the evaluation index to conduct L9(33) orthogonal test and the contents of salicyclic acid and the chloramphenicol were determined by HPLC. RESULTS: The optimized basic formula was as follows: sodium carboxymethylcellulose 3 g, glycerine 10 g, and alcohol 35 mL.The average recovery of Salicylic Acid and Chloramphenicol were 99.1% and 101.6%,the RSD were 0.8% and 1.3%.CONCLUSION: The basic formula optimized with orthogonal test is proved to be stable and serve as theoretic basis for the industrialized production of this preparation.
