Pharmacokinetics and Bioequiavailability of Loratadine Tabletes in Healthy Volunteers
- VernacularTitle:氯雷他定片人体药动学及生物等效性研究
- Author:
Cuilan WANG
;
Shenglin WU
;
Li LIU
- Publication Type:Journal Article
- Keywords:
Loratadine;
Solid phase extraction-HPLC;
Bioequivalence
- From:
China Pharmacy
2005;0(23):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the bioequiavailability of two kinds of loratadine tabletes in Chinese healthy volunteers.METHODS:A single oral dose 40 mg of two loratadine preparations(reference and test preparations)was given to 20 volunteers(whom were divided into two groups)in a randomized cross-over study.The concentration of loratadine in plasma was determined by solid phase extraction-HPLC.RESULTS:The main pharmacokinetic parameters of reference and test preparations were as follows:Cmax were(17.00?3.90)and(18.41?2.58)?g?L-1;tmax were(1.06?0.25)and(0.93?0.20)h;t1/2Ke were(1.34?0.38)and(1.08?0.38)h;AUC0～∞ were(37.41?17.38)and(36.38?16.73)?g?h?L-1;AUC0～8 were(35.11?15.72)and(34.76?15.34)?g?h?L-1,respectively.The relative bioavailability of the test preparation was(99.0?18.7)% as against the reference preparation,and no significant differences was noted for the two formulations in ANOVA and two-one side t test.CONCLUSION:The two formulations were bioequivalent.
