The Clinical Observation of Salina and Vitamin E Application in Nonsmall-cell Lung Cancer Patients Treated by Chemotherapy
- VernacularTitle:盐藻素+维生素E对非小细胞肺癌患者化疗不良反应的临床研究
- Author:
Guoxing LI
;
Yilan LI
;
Changli WANG
- Publication Type:Journal Article
- Keywords:
Nonsmall-cell lung caner;
Vitamin E;
Salina;
Chemotherapy;
Side effects
- From:
Chinese Journal of Prevention and Control of Chronic Diseases
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of salina and vitamin E on the antiadverse reaction in nonsmall-cell lung cancer patients treated by chemotherapy. Method 124 cases nonsmall-cell lung cancer patients were selected during December, 2005 and December, 2007. Patients were randomly divided into two groups: A and B group, which were treated by salina plus vitamin E and placebo respectively. First, all patients were treated by radical operation. After operation, conventional chemotherapy (TAX+CBP) was followed. The day before chemotherapy, salina and vitamin E was oral administered to A group until before the third chemotherapy. The interval between chemotherapy was 3 weeks. B group was treated by the same way with placebo. Prior to the third chemotherapy, blood routine examination, liver and kidney function, immune index and antioxidation index were detected. Results After treatment, leukocyte number increased in A group, but decreased in B group. There was no obvious damage founded in liver and kidney function. CHE level was significantly enhanced in A group. The level of SOD in A group was significantly higher than that in B group. Conclusion salina+vitamin E could reduce the leukocyte number decrease caused by chemotherapy, increase the activity of cholinesterase, and enhance the antioxidation function of patients, so it can protect some side effects of chemotherapy in non-small lung cancer patients.
