Recent advance in macrophage pattern recognition receptors for lipopolysaccharide recognition
- VernacularTitle:巨噬细胞LPS相关模式识别受体的研究进展
- Author:
Ning DING
;
Yong JIANG
- Publication Type:Journal Article
- Keywords:
Macrophages;
Lipopolysaccharides;
Pattern recognition receptors;
Sepsis
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is systemic inflammatory response syndrome(SIRS)associated with the presence of pathogenic microorganisms or their toxin.Lipopolysaccharide(LPS)is an important component of the outer membrane of Gram negative bacteria and has a pivotal role in inducing Gram negative sepsis.Macrophages play an essential role in infection and inflammation.Specific recognition of LPS is of particular importance in the defense system and pattern recognition receptors(PRR)have been considered to be important in initial steps for cellular recognition of LPS and consequence initiation of LPS responses.In the past few years,intense research in the fields of PRR and their recognition mechanism has been achieved.In this review,we attempt to expound recent research advances of macrophage PRRs for LPS recognition and their mechanism.
