Effects of TAE and TACE on HIF-1?,MVD and PCNA in rabbit liver carcinoma
- VernacularTitle:TAE和TACE治疗对兔肝癌HIF-1?,MVD和PCNA的影响
- Author:
Jinlong CHEN
;
De HE
- Publication Type:Journal Article
- Keywords:
Liver Neoplasms/ther;
Chemoembolization,Therapeutic;
Hypoxia Inducible Factor;
Proliferating Cell Nuclear Antigen
- From:
Chinese Journal of General Surgery
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate expression and clinical significance of HIF-1?、MVD and PCNA after TAE or TACE for rabbit liver carcinoma,and to identify the mechanism of hepatic carcinoma cell proliferation after the operation.Methods Thirty rabbits were implanted with liver VX2 tumors for 1 week.Then they were randomly divided into 3 groups.Control group had hepatic arterial infusion of 0.5 to 0.8 mL saline.TAE group was embolized with 0.5 to 0.8 ml UFLP.TACE group was embolized with 0.5 to 0.8 ml UFLP mixed with 2 mg THP.Two weeks after treatment,HIF-1?、MVD and PCNA expression was detected.Results Growth of the liver tumor was found in the 3 groups,and there were 15,11 and 3 new tumors found in the control group,TAE group and TACE group respectively.The expressions of HIF-1?and PCNA in control group were higher than those in TACE group,but significantly lower than those in TAE group(P
