Effects of aminophylline used in the early stage of resuscitation on adenosine and vaso-active factors
- VernacularTitle:复苏早期应用氨茶碱对腺苷及血管活性因子的影响
- Author:
Xiurong XING
;
Jian QIN
;
Yanchuan WU
;
Jing WANG
;
Dongmei HAO
- Publication Type:Journal Article
- Keywords:
Resuscitation;
Aminophylline;
Adenosine;
Endothelin-1;
Nitric oxide
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the effects of aminophylline used early in resuscitation on achievement ratio of resuscitation,the concentrations of plasma norepinephrine(NE),adenosine and nitric oxide(NO),and the levels of cardiac tissue endothelin-1(ET-1)and adenosine in rats with sudden cardiac arrest.METHODS:Sixty SD rats were randomly divided into three groups:operated control(group A),epinephrine treatment(group B),and epinephrine plus aminophylline treatment(group C).Each group had 20 rats.The concentrations of plasma NE,adenosine and NO,and the levels of cardiac tissue ET-1 and adenosine were examined in group A and 30 min after survived in group B and group C.RESULTS:The duration of circulation recovered in group C was less than that in group B,significantly(P0.05).The concentrations of plasma adenosine and NE,and the levels of cardiac tissue ET-1 and adenosine in group B and group C were higher than those in group A significantly(P
