Effect of Isatin on the Activities of Antioxidase in PD Model Mice
- VernacularTitle:2,3-吲哚醌对帕金森病模型小鼠抗氧化酶活性的影响研究
- Author:
Fang ZHANG
;
Wang YUE
- Publication Type:Journal Article
- Keywords:
ISA;
Parkinson's disease model;
Selegiline;
Antioxidase;
Mice
- From:
China Pharmacy
2005;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the possible mechanism of the neuroprotective action of isatin(ISA).METHODS:A total of 40 C57BL/6J mice were divided into 4 groups:control group,model group,ISA(200 mg?kg-1 intragastrically) group,and selegiline(0.5 mg?kg-1 intraperitoneally) group.After pretreatment with drugs for 10 days,the latter 3 groups were given 1-methyl-4-phenyl-1,2,3,6-tetrahyrdropyridine(MPTP) intraperitoneally to establish Parkinson's disease(PD) model,then the mice were put to death for the determination of the activities of MAO-B,SOD and GSH-px in blood serum and brain tissue.RESULTS:As compared with blank control group,the activity of MAO-B in model group increased slightly,while the activities of SOD and GSH-px decreased(P
