Thermal Stability and Thermal Decomposition Kinetics of Ciprofloxacin Hydrochloride
- VernacularTitle:盐酸环丙沙星的热稳定性和热分解反应动力学研究
- Author:
Xiaomei ZHU
- Publication Type:Journal Article
- Keywords:
Ciprofloxacin hydrochloride;
Thermal decomposition kinetics;
Thermogravimetric analysis;
Differential scanning calorimetry;
Thermal stability
- From:
China Pharmacy
2005;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the process and mechanism of thermal decomposition of ciprofloxacin hydrochloride(CPLX).METHODS:With Al2O3 as reference substance,the samples in nitrogen gas were analyzed by differential scanning calorimetry(DSC),thermogravimetry(TG),digital thermogravimetry(DTG).The thermal kinetic parameters including the energy of activation(E),pre-exponential factor(A),reaction order(n) and pk value were computed based on the data of the thermal analysis curves.RESULTS:The thermal kinetic parameters were as follows:E=101.18 kJ?mol-1,lnA=26.96 s-,n=1,and pk=7.01,and the storage life of ciprofloxacin hydrochloride under normal temperature was 2 years.CONCLUSION:The thermal analysis method is simple and the result is reliable in the study of thermal decomposition of ciprofloxa-cin hydrochloride.
