Preparation of Urapidil Osmotic Pump Tablets
- VernacularTitle:乌拉地尔渗透泵片的制备
- Author:
Cuiyan HAN
;
Nan XU
;
Changjiang SHENG
- Publication Type:Journal Article
- Keywords:
Urapidil;
Osmotic pump tablet;
Controlled release;
Uniform design;
Similarity factor
- From:
China Pharmacy
2005;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare urapidil osmotic pump tablet(OPT) characterized by 24 h constant drug release in vitro.METHODS:OPT of urapidil was prepared using NaCl and low or high moleculan weight PEO(Mr 4?106、2?105) as core,CA and PEG-400 as the coating material.Similarity factor was used to evaluate formulation of osmotic pump tablets.The drug release mechanism was investigated as well.RESULTS:The optimal core formulation consisted of urapidil 60 mg,NaCl 190 mg,PEO(Mr 4?106) 90 mg,PEO(Mr 2?105) 90 mg.The drug was released from OPT at controlled rate 24 h.CONCLUSION:The preparation of osmotic pump tablets was simple and characterized by zero-order release.
