Preparation of Cefuroxime Axetil Bitter-masked Pellets
- VernacularTitle:头孢呋辛酯掩味微丸的制备
- Author:
Shixia GUAN
- Publication Type:Journal Article
- Keywords:
Cefuroxime axetil;
Bitter masked pellets;
Loading dosage;
Dissolution
- From:
China Pharmacy
2005;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare bitter masked-pellets of cefuroxime axetil.METHODS:Cefuroxime axetil pellets were prepared by means of powder layering with the centrifugal granulation equipment,cefuroxime axetil pellets were coated in a fluid-bed equipment and the bitter was masked,and the dissolution of the preparation was determined.RESULTS:The recovery of the pellets between 40～50 meshes and yield rates was 89.5%;the drug content was 6.29% and the dissolution was 80% at 45 min.CONCLUSION:Bitter masked-pellets of cefuroxime axetil can be prepared by the fluid-bed coating method.
