Preparation and Dissolution Rate of Inclusion Complex Capsules of Actarit-HP-?-CD
- VernacularTitle:阿克他利-羟丙基-?-环糊精包合物胶囊的制备及溶出度考察
- Author:
Wenwen ZHANG
;
Yujie DAI
;
Lingyun ZHU
- Publication Type:Journal Article
- Keywords:
Actarit;
Hydroxypropyl-?-cyclodextrin;
Inclusion complex;
Capsule;
Dissolution rate
- From:
China Pharmacy
2005;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare the inclusion complex capsules of actarit-HP-?-CD and investigate their dissolution rate.METHODS:The inclusion complex was prepared by the stirring method with its dissolution rate investigated.The inclusion complex capsules were prepared with fillers consisted of starch,microcrystalline cellulose,lactose and calcium sulphate.The dissolution rate of the capsules was investigated by basket-stirring method and compared with those of the pure material and the physical mixture.RESULTS:Compared with pure material and physical mixture,the inclusion complex had significant lower value of Td(P
