Preparation and Quality Control of Penciclovir Hollow Suppository
- VernacularTitle:喷昔洛韦中空栓的制备及质量控制
- Author:
Jianhua CHEN
- Publication Type:Journal Article
- Keywords:
Penciclovir hollow suppository;
Preparation;
Quality control
- From:
China Pharmacy
2005;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare penciclovir hollow suppository and establish its quality control method.METHODS:Penciclovir hollow suppository was prepared by heat-melting method.The content of penciclovir was determined by HPLC and the stability of the suppository was investigated as well.RESULTS:The preparation was ivory yellow hollow suppository and its property fitted the description of Chinese Pharmacopeia(2005 edition).The linear range of penciclovir was 5.00～100.00 ?g?mL-1(r=0.999 7),and its average recovery was 98.69%(RSD=0.81%).No obvious change was noted for the property of the suppository within 1 year storage under temperature away from light.CONCLUSION:The preparation technique of the penciclovir hollow suppository is simple and feasible,its quality control method is rapid in operation and its determination result is accurate and reliable.
