Evaluation of Dissolution of Azithromycin Tablets from 5 Pharmaceutical Factories
- VernacularTitle:不同厂家阿奇霉素片溶出度评价
- Author:
Suying MA
;
Xiaojun SHANG
;
Xiangde SUN
- Publication Type:Journal Article
- Keywords:
Azithromycin tablet;
Dissolution;
Evaluation;
UV spectrophotometry
- From:
China Pharmacy
2005;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish a method for the determination of the dissolution rates of azithromycin tablets and to compare the dissolution rates among azithromycin tablets that from different manufacturers so as to provide references for clinical medication.METHODS:The concentrations and drug cumulative dissolution rates of a total of 5 batch numbers' azithromycin tablets that from 5 pharmaceutical factories were determined based on the related standard procedure indexed in China Pharmacopoeia(2005 edition),then the dissolution parameters were calculated with Weibull formula.RESULTS:The dissolution rates at 45 min were above 75%,which was up to the standard.The analysis of variance showed that there were significant differences among samples in dissolution parameters(P
