Effects of Rhizoma Sparganii and Rhizoma Curcumae on the Angiogenesis of Newly Born Tissue in Artificial Sponge in Rats
- VernacularTitle:三棱、莪术对大鼠皮下移植人工海绵新生血管的影响研究
- Author:
Lan YE
- Publication Type:Journal Article
- Keywords:
Rhizoma Sparganii;
Rhizoma Curcumae;
Angiogenesis;
Vascular endothelial cell growth factor(VEGF)
- From:
China Pharmacy
2005;0(21):-
- CountryChina
- Language:Chinese
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Abstract:
OBJECTIVE:To explore the inhibitory effects and mechanism of Rhizoma Sparganii and Rhizoma Curcumae on the angiogenesis of new granulation tissue in sponge.METHODS:The experimental endometriosis in female rats was established with sponge implantation.The effects of Rhizoma Sparganii and Rhizoma Curcumae on the angiogenesis of new granulation tissue in sponge were observed after intragastric medication for 2 consecutive weeks.The staining of endothelial cell specific Ⅷ factor and vascular endothelial cell growth factor(VEGF) was carried out by immunohistochemistry method.The expression of VEGF mRNA was detected by RT-PCR assay.RESULTS:In rats receiving high dosage of Rhizoma Sparganii and Rhizoma Curcumae(SC),the area of new granulation tissue in sponge,the number of blood vessels,the expression of VE-GF and VEGF mRNA were all significantly lower than in model group(P
