Permeation Enhancing Effect of Flos Caryophylli Volatile Oil Versus Azone on Diclofenac Sodium
- VernacularTitle:丁香挥发油与氮酮对双氯芬酸钠促透作用的比较研究
- Author:
Dong HUANG
;
Guangbin CHEN
- Publication Type:Journal Article
- Keywords:
Flos Caryophylli volatile oil;
Azone;
Diclofenac sodium;
Permeation enhancing effect
- From:
China Pharmacy
2005;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the permeation enhancing effect of Flos Caryophylli volatile oil versus azone on diclofenac sodium.METHODS:Percutaneous absorption experiment was performed on the apparatus of isolated skin,and the penetrated amounts of diclofenac sodium at different time were measured,then the steady-state flux and enhancing rate were calculated,and the deposit effect of diclofenac sodium was investigated.RESULTS:Flos Caryophylli volatile oil and azone all had promotion effect on percutaneous absorption of diclofenac sodium,especially when they used in combination.Used either in combination or alone,they all had remarkable enhancement property on deposit effect of diclofenac sodium(P
