Oxaliplatin Combined with Paclitaxel and Fluorouracil for Advanced Colorectal Cancer: Clinical Observation
- VernacularTitle:奥沙利铂联合紫杉醇、5-氟尿嘧啶治疗中晚期大肠癌的临床观察
- Author:
Hongliang DONG
;
Jianqun LIANG
- Publication Type:Journal Article
- Keywords:
Oxaliplatin;
Paclitaxel;
5-Fluorouracil;
Advanced colorectal cancer;
Combined chemotherapy
- From:
China Pharmacy
2005;0(20):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the clinical curative effect and adverse reaction of oxaliplatin combined with paclitaxel and fluorouracil in the treatment of advanced colorectal cancer.METHODS: 189 cases with advanced colorectal cancer were randomly divided into two groups: Group A(n=94) received oxaliplatin combined with paclitaxel and fluorouracil,and Group B(n=95) to receive oxaliplatin combined with fluorouracil.Both groups were treated with 3 cycles(21 days in every cycle).RESULTS: The total effective rate in Group A was 54.3% versus 40.0% in Group B;and the toxicity in Group A was less severe than in Group B(P
