Protective effect of propofol delivered through portal vein on hepatic ischemia reperfusion injury in rabbits
- VernacularTitle:门静脉注射异丙酚对家兔肝脏缺血再灌注损伤的保护作用
- Author:
Dangjun ZHOU
;
Yi LU
;
Dongjun AN
;
Yao LUO
;
Cheng ZHANG
- Publication Type:Journal Article
- Keywords:
Liver/blood supply;
Ischemia Reperfusion Injury;
Propofol;
Endothelin-1;
Nitric Oxide;
Adenosine Triphosphate
- From:
Chinese Journal of General Surgery
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the protective effect of portal vein administration of propofol on hepatic ischemia reperfusion injury(HIRI) and its mechanism.Methods Thirty-two male rabbits were randomly allocated into four groups:Group A(sham operation group),the abdomen was only opened and closed;group B,the hepatic inflow was occluded for 30 min,and reperfused for 60 min;group C,the same managment as group B + propofol injected through jugular vein;group D,the treatment same as group B + propofol injected through portal vein.Drug injection was completed 20 min before hepatic inflow occlusion.Serum ALT and AST,and endothelin-1(ET-1) and nitric oxide(NO)in the hepatic tissue and blood,and the content of ATP in hepatic tissue were determined.Results The level of ET-1 in plasma and hepatic tissue was significantly increased in group B compared to group C and D(P
