Inhibitory Effect of Phenolicalkaloids of Menispermum Dauricum on the BXPC-3 Tumor and Its Effect on iNOS Content in Tumor-bearing Mice
- VernacularTitle:蝙蝠葛酚性碱对BXPC-3荷瘤抑制作用及iNOS含量的影响研究
- Author:
Xiying WEN
- Publication Type:Journal Article
- Keywords:
Phenolicalkaloids of menispermum dauricum(PAMD);
Inducible nitric oxide synthase(iNOS);
Human pancreatic cancer cell line(BXPC-3)
- From:
China Pharmacy
2005;0(18):-
- CountryChina
- Language:Chinese
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Abstract:
OBJECTIVE:To observe the inhibitory effect of phenolicalkaloids of menispermum dauricum(PAMD)on the human pancreatic cell line(BXPC-3)tumor and study the effect of PAMD on serum content of inducible nitric oxide synthase(iNOS)in tumor-bearing mice.METHODS:The BXPC-3 tumor-bearing mice model was established,and the model mice were randomly assigned to 6 groups:model control group,blank control group,cyclophosphamide group,3 PAMD groups(high,medium and low dosages).The blank control group was not inoculated with tumor strain but given same volume of normal saline.The tumor-inhibition ratio of PAMD was detected and the content of iNOS of in peripheral blood of tumor-bearing mice was determined by fluorospectrophotometry.RESULTS:PAMD(high,medium and low dosages)showed marked inhibitory effect on tumor growth of BXPC-3 cell line in tumor-bearing mice,with the inhibition ratios at 34.91%,52.83% and 41.51%,respectively.As compared with model control group,PAMD-treated groups showed significantly lower content of iNOS in peripheral blood of tumor-bearing mice.CONCLUSION:PAMD showed marked inhibitory effect on tumor growth of BXPC-3 cell line in tumor-bearing mice,which might be attributed to the lowered content of iNOS.
