Changes of cardiac energy metabolism and structure during ischemia/reperfusion injury of liver in rats
- VernacularTitle:大鼠肝缺血再灌注损伤对心脏能量代谢和结构的影响及其机制
- Author:
Xiaojuan MA
;
Hongmei WANG
;
Jianlong ZHANG
;
Qi MA
;
Wenyan YU
;
Jun LIAN
;
Fengcai JI
;
Jie YU
- Publication Type:Journal Article
- Keywords:
Ischemia reperfusion injury;
Heart;
Endotoxin;
Energy metabolism;
Structure
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the effect and mechanism of liver ischemia/reperfusion(I/R)injury on the changes of cardiac energy metabolism and structure.METHODS:48 healthy Wistar male rats were randomly divided into 6 groups as follows(n=8 in each group):control group(CTL),simply ischemia for 30 min without reperfusion(I group);reperfusion following ischemia for 30 min(I/R group);2 h reperfusion following ischemia for 30 min(I/R 2 h group);4 h reperfusion following ischemia for 30 min(I/R 4 h group)and 6 h reperfusion following ischemia for 30 min(I/R 6 h group).The level of serum endotoxin was measured.The levels of insulin and insulin antibody in heart were detected by radioimmunoassay.The contents of MDA,MPO and lactic acid in heart were also determined.RESULTS:During the process of liver I/R injury,the level of endotoxin increased in I group and I/R group and declined gradually for long time during reperfusion,but was still longer than that in CTL group(P0.05).CONCLUSION:During the process of liver I/R injury,endotoxin is absorbed from intestine and impairment of liver detoxication leads to endotoxemia,which might play a role in the changes of the energy metabolism and structure in heart.
