Progress in a new proto-oncogene of Wip1
- VernacularTitle:原癌基因Wip1的研究进展
- Author:
Wei ZHANG
;
Yong GU
;
Honghe LUO
;
Jixing ZHAO
- Publication Type:Journal Article
- Keywords:
Genes,Wip1;
p38 MAP kinases;
Protein p53
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Wip1 is a nuclear protein and a member of serine/threonine specific protein phosphatase type 2C(PP2C)family.It was initially identified as a gene whose expression was induced in response to ? or UV radiation in a p53-dependent manner and a negative feedback regulation of p38MAPK-p53 signaling.Then,Wip1 gene was confirmed a proto-oncogene and amplified or overexpressed in several human tumor types.This review will introduce the structures and functions of Wip1 and details on the signaling process of cancer progression.
