Protein Z intron FG79A polymorphisms are not associated with coronary artery disease
- VernacularTitle:冠心病与蛋白Z内含子FG79A基因多态性无关联
- Author:
Hong SHAO
;
Geng XU
;
Lixuan WU
;
Baiming QU
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Protein Z;
Gene polymorphism;
Chinese Han population
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the distribution of protein Z intron FG79A polymorphisms in Chinese and the associations with coronary artery disease(CAD).METHODS:148 patients were performed selected coronary angiography and more than one major coronary vessel with at least 50% stenosis was defined as CAD.The control group consisted of 147 subjects.The protein Z intron FG79A polymorphisms were studied by polymerase chain reaction and restriction fragment length polymorphism and parts of PCR products were sequenced.RESULTS:Protein Z intron FG79A polymorphisms were first recovered in Chinese,and the frequencies of G and A alleles were 44.24% and 55.76%,respectively.The frequencies of two alleles were not significantly different between patients and controls.There was no significant difference in protein Z intron FG79A genotype distribution among patients with one,two or three stenosed vessels.No significant difference was found among the frequencies of the three genotypes between both acute coronary syndrome(ACS)and non-ACS.CONCLUSION:Protein Z intron FG79A polymorphisms are present in Chinese.Protein Z intron FG79A polymorphisms were not associated with CAD and ACS.
