Determination of in Vitro Percutaneous Rate of Kechuan Xuewei Patch and Its in Vitro Release Profile
- VernacularTitle:咳喘穴位贴片体外透皮速率和体外释放规律研究
- Author:
Liping YANG
- Publication Type:Journal Article
- Keywords:
Kechuan xuewei patch;
Percutaneous absorption;
Ephedrine
- From:
China Pharmacy
2005;0(18):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the determination method of the percutaneous rate of Kechuan xuewei patch and its in vitro drug release profile.METHODS:The content of ephedrine hydrochloride(an index composition)in percutaneous reception fluid and release fluid were determined by HPLC,and the percutaneous penetration rate and the in vitro drug release rate were computed.RESULT:Ephedrine permeated at a constant rate of 6.467 9 ?g?cm-2?h-1/2 and the in vitro drug release rate was 21.382 ?g?cm-2?h-1/2,fitting Higuchi equation.CONCLUSION:Kechuan xuewei patch can be prepared as controlled release matrix system of skin permeation rate-limited type.
