Rapamycin inhibits HMGB1 expression and releases in RAW264.7 cells induced by lipopolysaccharides in vitro
- VernacularTitle:雷帕霉素抑制LPS诱导的RAW264.7细胞表达和释放HMGB1的机制
- Author:
Zhongfu ZHAO
;
Dewu HAN
;
Yun ZHANG
;
Mingshe LIU
;
Guoying ZHANG
- Publication Type:Journal Article
- Keywords:
Rapamycin;
High mobility group proteins;
RAW264.7 cells;
Tumor necrosis factor
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05).Both HMGB1 mRNA expression and HMGB1 protein level were remarkably higher in LPS treatment group than that in control group(P0.05).CONCLUSION:RPM inhibits HMGB1 expression not only by directly suppressing STAT3 activation,but also by indirectly reducing TNF-? level.
