Protective Effects of Galactoside-modified Oleanolic Acid Solid Lipid Nanoparticles on CCl_4-induced Acute Hepatic Injury in Rats
- VernacularTitle:经半乳糖苷修饰的齐墩果酸固体脂质纳米粒对急性肝损伤模型小鼠的保护作用研究
- Author:
Jingwen WANG
;
Aidong WEN
;
Haifeng TANG
;
Li WANG
;
Dan LIU
- Publication Type:Journal Article
- Keywords:
Oleanolic acid solid lipid nanoparticles;
Hepatic injury;
Mice;
CCl4;
Protective effect
- From:
China Pharmacy
2005;0(19):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the protective effect of galactoside-modified oleanolic acid solid lipid nanoparticles(OA-G10SLN)on CCl4-induced acute hepatic injury of rats.METHODS:A total of 60 mice were assigned to normal control group,model group,OA regular solution group or OA-G10SLN group(25.0,12.5,and 2.5 mg?kg-1).Each group was injected from venal caudalis with corresponding drug q.d.for 7d.Acute hepatic injury model was induced by CCl4 on day 6 after medication except for the normal control group.The mice were sacrificed at d7 with serum levels of AST and ALT determined and histopathologic test of liver tissues performed.RESULTS:In OA-G10SLN group compared with model group,the serum levels of AST and ALT decreased markedly(P
