Mechanism of Ademetionine for Treating Hyper-unconjugated Bilirubinemia in Neonate Rats
- VernacularTitle:腺苷蛋氨酸治疗新生大鼠高未结合胆红素血症作用机制的研究
- Author:
Tubing SI
;
Qiliang CUI
;
Xiangping TAN
- Publication Type:Journal Article
- Keywords:
Ademetionine;
Neonate rats;
Hyper-unconjugated bilirubinemia
- From:
China Pharmacy
2005;0(19):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the efficacy and mechanism of ademetionine for treating hyper-unconjugated bilirubinemia in neonate rats.METHODS:The model of hyper-unconjugated bilirubinemia was established in 95 neonate SD rats by subcutaneously injection of phenylhydrazine hydrochloride,then the rats were randomly assigned to model control group(treated with normal saline),therapeutic control group(phenobarbital/nikethamide)and the therapeutic group(s-adenosyl-1-methionine)q.d for 7 days all by intraperitoneal injection.Blood samples were taken at different time for the analysis of the hepatic BUGT activity and serum bilirubin.RESULTS:In therapeutic control group compared with the model control group,the serum unconjugated bilirubin was lower,and the hepatic BUGT activity of therapeutic was higher(P
