Absorption Kinetics of Simvastatin in Rats
- VernacularTitle:辛伐他汀大鼠肠吸收动力学研究
- Author:
Lihua ZHAO
;
Yupeng WANG
- Publication Type:Journal Article
- Keywords:
Simvastatin;
Absorption kinetics;
In vivo;
Dosage form design
- From:
China Pharmacy
2005;0(19):-
- CountryChina
- Language:Chinese
-
Abstract:
0.025 63 h-1).A linear relation between absorption and concentration was noted for simvastatin at a concentration of 1.0～20.0 ?g?mL-1;and within a pH value of 5.0～7.4,the absorption of simvastatin was not affected.CONCLUSION:Simvastatin showed absorption behavior in the whole section of intestine.The absorption of the drug conforms to the passive transport mechanism and first-order kinetics.The results indicate that simvastatin can be formulated and prepared into sustained-release drug delivery system.
