Effects of High Protein Diet on Pharmacokinetics of Gatifloxacin on Dogs
- VernacularTitle:高蛋白饮食对犬加替沙星药动学的影响研究
- Author:
Bin ZHANG
;
Huarong WANG
- Publication Type:Journal Article
- Keywords:
High protein diet;
Gatifloxacin;
Dogs;
Pharmacokinetics
- From:
China Pharmacy
2005;0(19):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effect of high protein diet on pharmacokinetics of gatifloxacin.METHODS:A randomized crossover design was performed in 8 Beagle dogs.In the two study periods,a single oral 17 mg?kg-1 dose was administered to empty stomach or with high protein diet in dogs.Plasma concentration of gatifloxacin were measured by HPLC.The pharmacokinetic parameters were calculated by 3p97.RESULTS:The concentration-time curves were a one compartment model in empty stomach or with high protein diet in beagle dogs.The t1/2ke were(4.00?0.84)and(9.28?1.32)h,tmax(2.29?1.08)and(4.98?2.76)h,Cmax(6.06?0.87)and(3.42?1.20)?g?mL-1,AUC(0～t)(56.74?10.80)and(68.66?15.92)?g?h?mL-1,respectively.There was significant difference between the two groups in the main pharmacokinetic parameters(P
