Effect of Minidose Aspirin on Uric Acid in Hyperuricemia Model Mice
- VernacularTitle:微小剂量阿司匹林对高尿酸血症模型小鼠血尿酸的影响考察
- Author:
Haiying ZHANG
;
Yuzhen LI
- Publication Type:Journal Article
- Keywords:
Aspirin;
Hyperuricemia model;
Mice;
Blood uric acid;
Creatinine;
Urea nitrogen
- From:
China Pharmacy
2005;0(19):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the effects of minidose aspirin on blood uric acid,creatinine and urea nitrogen in hyperuricemia model mice.METHODS:75 mice were randomly assigned to receive 0.5% CMC-Na(normal control group and hyperuricemia control group)or aspirin(12.5,25,50 mg?kg-1?d-1)q.d for 1 week.Then all the mice except the normal control group were intraperitoneally administered with uric acid to establish hyperuricemia model.1 h later,the blood sample was collected for determination of uric acid,creatinine and urea nitrogen.RESULTS:As compared with hyperuricemia control group,mini-dose aspirin had no apparent effect on creatinine and urea nitrogen,but remarkably increased the level of blood uric acid(P
