Preparation of Quality Control of Chloramphenicol and Ephedrine Nasal Gel
- VernacularTitle:氯麻滴鼻凝胶的制备及质量控制
- Author:
Ping DENG
;
Tao SHI
;
Feng SHAO
;
Danling LIN
- Publication Type:Journal Article
- Keywords:
Chloramphenicol and ephedrine nasal gel;
Chloramphenicol;
Ephedrine hydrochloride;
Preparation;
Quality control
- From:
China Pharmacy
2005;0(19):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare chloramphenicol and ephedrine nasal gel and establish its quality control method.METHODS:Gel was prepared with chloramphenicol and ephedrine hydrochloride as principal agents and with carbomer-940 as base.The contents of the principal agents were determined by HPLC and the stability of the gel was investigated as well.RESULTS:The preparation was transparent colloid.The linear ranges of chloramphenicol and ephedrine hydrochloride were 62.5～1 000 and 31.25～500 ?g?L-1(r=0.999 9),respectively,with average recovery rates at 99.64%(RSD=0.5%)and 99.57%(RSD=0.7%),respectively.Storing under room temperature,no obvious change was noted for the property of the sample at 12 months.CONCLUSION:The preparation technique of the gel is simple and feasible,and its quality is stable and controllable.
