Test Method of Bacterial Endotoxin in Ceftazidime/Tazobactam Sodium for Injection
- VernacularTitle:注射用头孢他啶/他唑巴坦钠细菌内毒素检查方法研究
- Author:
Li CUI
- Publication Type:Journal Article
- Keywords:
Ceftazidime /tazobactam sodium;
Bacterial endotoxin;
Tachypleus amebocyte lysate;
Interference test
- From:
China Pharmacy
2005;0(19):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish a method for testing the bacterial endotoxin in ceftazidime/tazobactam sodium for injection.METHODS:Based on the bacterial endotoxin test method stated in Chinese Pharmacopoeia(2005 edition),an interference test was conduced on different batches No.of ceftazidime/tazobactam sodium samples using actachypleus amebocyte lysate(TAL)from different companies.RESULTS:No interference was found in the bacterial endotoxin test after ceftazidime/tazobactam sodium for injection was diluted to 5.0 mg?mL-1.Its limit value of bacterial endotoxin was 0.1 EU?mL-1.CONCLUSION:Actachypleus amebocyte lysate test was suitable for determining bacterial endotoxin in ceftazidime/tazobactam sodium for injection.
