Monitoring of Blood Drug Level of Digoxin and the Analysis of Results
- VernacularTitle:我院地高辛血药浓度监测结果分析
- Author:
Yingbiao TIAN
;
Zehui CHEN
;
Changhua CHENG
;
Shiming WANG
;
Min WANG
;
Yong HE
- Publication Type:Journal Article
- Keywords:
Digoxin;
Blood drug level monitoring;
Rational administration
- From:
China Pharmacy
2005;0(17):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To detect the blood drug level of digoxin in order to offer reference about clinical safety and utility and rational use of cardiac glycoside drugs. METHODS: The plama concentration of digoxin was determined by fluorescence polarization immunization, and the monitoring rssults were subjected to statistical analysis. RESULTS: Of the total 126 cases who treated with digoxin, the blood drug concentration in 32(25.4%) was above 2.0 ng?mL-1,and it was 0.8～2.0 ng?mL-1 in 83(65.9%) and less than 0.8 ng?mL-1 in 11(8.7%); Toxic symptoms were noted in 16 cases(12.7%). CONCLUSION: To ensure clinical efficacy and reduce incidence of toxic reactions, it is of great importance to monitior the blood drug level and formulate individual dosage regimen.
