Activity of Ca~(2+).Mg~(2+)-ATPase and SDH in myocardium of rat induced by macleaya cordata and ultrastructures
- VernacularTitle:博落回对大鼠心肌Ca~(2+).Mg~(2+)-ATPase与SDH活性的影响及超微结构观察
- Author:
Maowang WU
;
Jianhua ZHU
;
Deyu ZHANG
- Publication Type:Journal Article
- Keywords:
Forensic pathology;
Macleaya cordata;
Ca2+.Mg2+-ATPase;
SDH;
Apoptosis
- From:
Chinese Journal of Forensic Medicine
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mechanism of the rat’s myocardium induced by macleaya cordata. Methods36 SD rats were randomly assigned to 2 experimental groups treated by macleaya cordata decoction with a dose of 1/6 LD50, 1/3 LD50 respectively and a control group treated with distilled water by oral administration. The rats were killed 6 hours after the administration for taking the cardiac muscle to examine the Ca2+.Mg2+-ATPase, SDH while observing the structures. ResoultsIn the group treated by macleaya cordata with dose of 1/6 LD50, the activity of Ca2+.Mg2+-ATPase and SDH were increased significantly.However, the groups treated by macleaya cordata with dose of 1/3 LD50 and distilled water, the activity of Ca2+.Mg2+-ATPase,SDH showed no significant change. The apoptosise in myocardium cells of rat’s can be observed in the experimental groups,while the changes were not seen in control group. ConclusionThe results indicate that the macleaye cordata can induce and improve the apoptosis of myocardium cells in low dose, and these effects may be induced by stimulating the activity of Ca2+.Mg2+-ATPase,SDH in myocardium cells.
