Protective Effects of Fucose and Vitamin E on Immune Suppression Caused by Chemotherapy in Model Mice
- VernacularTitle:盐藻素与维生素E联合改善化疗免疫抑制作用研究
- Author:
Guoxing LI
;
Tielin NING
;
Yilan LI
- Publication Type:Journal Article
- Keywords:
?-Carotene;
Vitamin E;
Immune function;
Interleukin 2
- From:
Chinese Journal of Prevention and Control of Chronic Diseases
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the protective effects of the combination of fucose and vitamin E on immune suppression caused by chemotherapy in model mice.Methods firstly,the model mice with lung adenoma were induced by urethane.Then the combination of fucose and vitamin E were administered to the mice after taking chemotherapy.T lymphocyte subpopulation and interleukin-2 concentration were detected by FCM to observe the change of immune function of the mice.Results Compared with chemotherapy control group,the combination of fucose and vitamin E could increase the percent of CD3+,CD4+,ratio of CD4+/CD8+ and the concentration of interleukin-2,but decrease the percent of CD8+.Conclusion The combination of fucose and vitamin E can obviously reduce the immune suppression caused by chemotherapy in mice.
