The Expression and Significance of VEGF and MMP-9 in Non-small Cell Lung Cancer
- VernacularTitle:血管内皮生长因子和基质金属蛋白酶-9在非小细胞肺癌中的表达及临床意义
- Author:
Tao LIN
;
Yongkui ZHANG
;
Hanbo LE
- Publication Type:Journal Article
- Keywords:
Non-small cell lung cancer(NSCLC);
Vascular Endothelial Growth Factor(VEGF);
Gelatinase B;
Endothelium,Vascular
- From:
Chinese Journal of Prevention and Control of Chronic Diseases
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the expression of Vascular Endothelial Growth Factor(VEGF) and Matrix Metalloproteinases-9(MMP-9) in non-small cell lung cancer(NSCLC) specimens and try to find out the possible roles of VEGF and MMP-9 in the invasion and metastasis of NSCLC.Methods Immunohistochemical SABC method was used to detect the expression of VEGF and MMP-9 in 23 non-cancerous pulmonary diseases tissues,30 normal lung tissues near the NSCLC and 111 NSCLC tissues.Results The expression levels of VEGF and MMP-9 in the NSCLC tissues were significantly higher than those of the control groups(P
