Effect of Ethyl Acetate Extract of the Seeds of Semem Hoveniae against Alcoholism
- VernacularTitle:枳椇子乙酸乙酯提取部位的解酒作用研究
- Author:
Tao SHI
- Publication Type:Journal Article
- Keywords:
The seeds of Semem Hoveniae;
Anti-alcoholism;
Ethyl acetate extract
- From:
China Pharmacy
2005;0(18):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study on the effect of ethyl acetate extract of the seeds of Semem Hoveniae.against alcoholism.METHODES:The mice were divided into four groups:model group(i.g.normal saline),positive group(i.g.Haiwangjinzun 20 g?kg-1),low-dose group of ethyl acetate extract(i.g.ethyl acetate extract 10 g?kg-1),and high-dose group of ethyl acetate extract(i.g.ethyl acetate extract 20 g?kg-1).The effects of different extracts on serum SGPT activity,MDA content and ADH activity,GSH content and SOD activity in liver tissue of mice with acute alcoholism were determined.RESULTS:Serum SGPT activity and MDA content were down-regulated while ADH activity,GSH content and SOD activity in liver tissue of acute alcoholism mice were up-regulated by the ethyl acetate extract of the seeds of Hovenia Dulcis Thunb.CONCLUSION:The ethyl acetate extract of the seeds of Semem Hoveniae exhibited remarkable anti-alcoholism efficacy,and which is worthy of further study.
