Determination of the Dissolution of Perospirone Hydrochloride Tablets
- VernacularTitle:盐酸哌罗匹隆片的溶出度测定
- Author:
Zhenghui HU
- Publication Type:Journal Article
- Keywords:
UV spectrophotometry;
Perospirone hydrochloride tablets;
Dissolution
- From:
China Pharmacy
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish a method for the determination of the dissolution of perospirone hydrochloride tablets(PHT).METHODS:The dissolution of PHT was determined in accordance with Chinese Pharmacopeia(2005 Edition) using water as solvent with the rotation speed at 50 r?min~(-1).The sample was taken at 30 minutes with its absorbability detected at a wavelength of 316 nm determinated by UV.Then the dissolution was calculated.RESULTS:The linear range of perospirone hydrochloride was 2～20?g?mL~(-1)(r=0.999 9)with an average recovery at 99.76%(RSD = 0.27%).The dissolutions of 3 batches of samples were all above 80%.CONCLUSION:The method was proved to be simple and reliable, and it can be used to determine the dissolution of PHT.
