Restoration of cardiac function in failing beagle hearts by recombinant adeno-associated viral gene transfer of sarcoplasmic reticulum Ca~(2+)-ATPase
- VernacularTitle:心肌肌浆网Ca~(2+)-ATP酶基因转导改善慢性心力衰竭犬心功能的研究
- Author:
Zhiqing FU
;
Xiaoying LI
;
Tao LIU
;
Yafei MI
;
Shengan ZHOU
;
Weihua YE
- Publication Type:Journal Article
- Keywords:
Heart failure,congestive;
Sarcoplasmic reticulum;
Ca~(2+)-transporting ATPase;
Gene transfer
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
29.3% decrease in ejection fraction).4 of 11 were used as heart failure group(HF,n=4).9 HF beagles were randomized to receive either a recombinant adeno-associated viral carrying the SERCA2a gene(HF+SERC A2a,n=5) or the reporter gene enhanced green fluorescent protein(HF+EGFP,n=4) by thoracotomy.All HF beagles paced by 180 beats/min in order to maintain failing state.Thirty days after infection,parameters of systolic and diastolic function were measured by doppler echocardiography and hemodynamic monitor in all beagles.RESULTS:At 30 days after gene transfer,symptoms of HF+SERCA2a dogs improved.Echocardiogram parameters were superior to those in HF+EGFP group(P
