Effect of elevated shear stress on caliber of abdominal aorta and aortic wall expression of matrix metalloproteinases-9 in rats
- VernacularTitle:剪切力增高对大鼠腹主动脉管径及管壁MMP-9表达的影响
- Author:
Yuanyuan GUO
;
Chang SHU
- Publication Type:Journal Article
- Keywords:
Aortic Aneurysm,Abdomen;
Arteriovenous Fistula;
Shear Stress;
Arterial Remodeling;
Matrix Metalloproteinase 9
- From:
Chinese Journal of General Surgery
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of elevated local sheer stress of abdominal aota on its caliber and wall expression of MMP-9,and analyse the action of high shear stress on arterial remodling.Methods Forty-eight SD rats were randomly divided into 4 experiment and 4 comparison groups.An infra-renal aortocaval fistula was constructed by needle puncture using a 0.4mm needle in the experiment groups.The aorta proximal to the fistula was harvested after 1 d,7 d,14 d and 28 d respectively,while sham operation was done in the comparison groups.The diameter and wall thickness of the aorta were measured after fistula was made and before harvest.The level of change of MMP-9 was observed by immunohistochemistry.Results The diameter of aorta proxinal to the fistula was enlarged in the 1d group(P
