Effect of combined thrombolysis and anticoagulation therapy on intimal changes of vein wall after acute thrombosis in rats
- VernacularTitle:溶栓抗凝联合治疗对大鼠急性血栓后血管内膜的影响
- Author:
Bing YANG
;
Qinghua ZHAO
;
Yu ZHAO
;
Xuehu WANG
;
Dongzhou XIANG
- Publication Type:Journal Article
- Keywords:
Venous Thrombosis/ther;
Tunica Intima/pathol;
Anticoagulation;
Thrombolysis
- From:
Chinese Journal of General Surgery
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the intimal changes of inferior caval vein(ICV) wall after combined thrombolysis and anticoagulation therapy for acute thrombosis in rats.Methods The inferior caval venous thrombosis model was established in 105 rats and they were randomly diride into 3 treated groups:heparin(A) treatment group(n=35),urokinase(B) treatment group(n=35),and combination of urokinase and heparin(C) treatment group(n=35),and also eslablished a sham(D) group(n=30).The thrombosed caval veins were taken 1,4,7,14,and 28 d after thrombosis.Changes of thrombus structure and orgainization and intimal hyperplasia were observed by light microscope.The expression areas of collagen fiber were measured by histochemistry.Scanning electron microscopy was used to observe the damage of endothelial cells.Results The intimal hyperplasia in A group was the most severe.The expression area of collagen fiber in group C was less than that of A and B groups(P
