Effects of rolipram on learning and memory and the activity of PDE4 in hippocampus following the focal brain injury induced by ischemia-reperfusion in rats
- VernacularTitle:咯利普兰对局灶性脑缺血-再灌注损伤大鼠学习记忆及海马PDE4活性的影响
- Author:
Xu LIU
;
Yufang CHENG
;
Hanting ZHANG
;
Jiangping XU
- Publication Type:Journal Article
- Keywords:
Rolipram;
Reperfusion injury;
cAMP;
Learning;
Memory
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the effects of rolipram on the ability of learning and memory and the activity of PDE4 in hippocampus following the focal brain injury induced by ischemia-reperfusion in rats.METHODS:The cerebral ischemia-reperfusion injury model was made by middle cerebral artery occlusion(MCAO) in rats.The rats were randomly divided into sham-operated group,model group,and rolipram group.Rolipram was administered once a day(1 mg/kg,ip) from 6 h after the onset of the operation for 2 weeks.Then the learning and memory abilities were tested after Morris water maze and step-though training.The activity of PDE4 in hippocampus was evaluated by HPLC.RESULTS:In the Morris water maze test,compared to sham-operated group,the platform-finding time and swimming distance in model group were significantly longer(P
