Effect of SR59230A as a ?_3 Adenoreceptor on Cardiac Function and ?_3-AR Expression in Rats with Heart Failure
- VernacularTitle:?_3肾上腺素能受体阻滞剂SR59230A对心力衰竭大鼠心功能及?_3肾上腺素能受体表达的影响
- Author:
Jihong LIN
;
Runtao GAN
;
Weimin LI
;
Xu WANG
;
Shuang WU
- Publication Type:Journal Article
- Keywords:
?3 Adenoreceptor;
Antagonist;
Rats;
Heart failure
- From:
China Pharmacy
2005;0(16):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To evaluate the effect of ?3 Adrenoceptor (?3-AR) antagonist SR59230A(SR) on cardiac function and expression of ?3-AR in rats with heart failure. METHODS: A total of 85 male Wistar rats were enrolled: 8 were as-signed to control group, and 77 were established into heart failure model and then 20 rats that modelled successly assigned ran-domly to placebo group or SR group, with placebo group intraperitoneally injected with normal saline and SR group with SR. The echocardiogram, hemodynamics, and expression of ?3-AR in rats after 7-week treatment were followed. RESULTS: In SR group compared with placebo group, shortening fraction, ejection fraction, left ventricular end systolic pressure, dp/dtmax and dp/dtmin were significantly higher (P
