Optimization of the Preparation Technology of Berberine Hydrochloride Solid Lipid Nanoparticles by Orthogonal Experiment
- VernacularTitle:正交试验优选盐酸小檗碱固体脂质纳米粒制备工艺
- Author:
Jun HOU
;
Shiwen ZHOU
- Publication Type:Journal Article
- Keywords:
Berberine hydrochloride;
SLN;
Preparation technology;
Orthogonal design;
Encapsulation
- From:
China Pharmacy
2005;0(15):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To prepare Berberine hydrochloride solid lipid nanoparticles(BH-SLN). METHODS: BH-SL-N was prepared by conventional rotary-evaporated film-ultrasonication method. Based on the single-factor experiment, BH-SLN was prepared using orthogonal design for optimization of formulation and technology. The quality of the obtained BH-SLN was evaluated. RESULTS:BH-SLN had even and regular appearance with a mean diameter of 60.5 nm,Zeta potential of —29.7 mV,drug loading of 8.69%, and entrapment ratio of 97.58%. CONCLUSION: The entrapment ratio of BH-SLN is high and the stability is good for BH-SLN prepared by conventional rotary-evaporated film-ultrasonication method, and the method is reliable.
